Song Lab-Research Overview

 

News

 

Congratulations to Dr. Gang Greg Wang's group, Dr. Jean G. Cook's group, and Zhi-Min on the story of BAHCC1 TTD and H40K20me1, published online in Nat Commun! 07/2025

Congratulations to Genevieve and Jian on the work of de novo DNA complex of ZMET2, published online in J Mol Biol!  05/2025 

Congratulations to Xinyi and Zengyu for winning the prestigious Wedding prize! 09/2024

Our work on the structure and function of DNMT3C has been published online in J Mol Biol. Congratulations to Nelli and All! 09/2024

Our work on the  allosteric regulation of Neurospora DIM2-mediated DNA methylation  has been published online in Nat Commun. Congratulations to Zengyu and All! 08/2024

Our work on the interaction between DNMT3A1 and H2AK119ub1-modified nucleosome, in collaboration with Drs. Gang Greg Wang and Yinsheng Wang's groups, has been published online in Nat Commun. Congratulations to Xinyi and All! 07/2024

Our work on the structure, mechanism and inhibition of DNMT3A R882 mutations, , in collaboration with Drs. Gang Greg Wang and Yinsheng Wang's groups, has been published online in Nat Commun. Congratulations to Jiuwei and All! 04/2024

 

Apply

 

Post-doctoral fellow and graduate student positions are available for highly motivated, hard-working candidates. We employ collaborative and multidisciplinary approaches to investigate mechanistic basis of cancer epigenetics, in particular chromatin modifications that are essential for gene regulation and cell development. The project will involve structural and dynamic characterization of macromolecular complexes involved in epigenetic programming, using combined biochemical approaches, including X-ray crystallography, cryo-EM, Single-molecule FRET and NMR spectroscopy. Applicants should hold a recent PhD degree and have significant experience in molecular cloning, protein production and protein biochemistry. Additional background in cryo-EM or microscopic imaging is considered a plus. Interested applicants should send curriculum vitae and contact information of 2-3 references to Dr. Jikui Song (jikui.song@ucr.edu).

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