Song Lab-Research Overview



Our work on DNMT1-H3K9me3 interaction has been published online in PNAS. Congratulations to Wendan and All! 07/2020

Congratulations to Linfeng and Boxiao for successful PhD defense! 06/2020

Our work on ZIKV NS5-STAT2 complex has been accepted in NSMB. Congratulations to Boxiao and All! 06/2020

Our work on DNMT3B-DNA complex has been published online in Nat. Commun, Congratulations to Linfeng and All! 06/2020

Our latest work on DNMT1-DNA complex has been accepted by Nat. Commun. Congratulations to Hiwot and Jiuwei! 06/2020

Our work on DNMT3A R882H-DNA complex has been published online in Nat. Commun. Congratulations to Hiwot and Jian! 05/2020


Post-doctoral fellow and graduate student positions are available for highly motivated, hard-working candidates. We employ collaborative and multidisciplinary approaches to investigate mechanistic basis of cancer epigenetics, in particular chromatin modifications that are essential for gene regulation and cell development. The project will involve structural and dynamic characterization of macromolecular complexes involved in epigenetic programming, using combined biochemical approaches, including X-ray crystallography, cryo-EM, Single-molecule FRET and NMR spectroscopy. Applicants should hold a recent PhD degree and have significant experience in molecular cloning, protein production and protein biochemistry. Additional background in cryo-EM or microscopic imaging is considered a plus. Interested applicants should send curriculum vitae and contact information of 2-3 references to Dr. Jikui Song (

Let us help you with your search